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The mitochondria-targeted antioxidant MitoQ has shown the ability to suppress NLRP3 inflammasome activation and promote microglial M2 polarization, thereby mitigating oxidative stress and neuroinflammation 34

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Therefore, it is suggested that impaired adaptive mechanisms, including lack of Akt activation and increased Parkin expression, render neurons from chronic mountain sickness subjects more susceptible to hypoxia-induced cell death [99]