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Similarly, LPS was reported to promote the migration and invasion of colorectal cancer by upregulating VEGFR-3 expression via increased binding of NF-κB to the promoter of VEGFR-3 [145]

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Given this situation, it is interesting that the literature on ascorbate functions in mammals, and particularly in work using cultured mammalian cells, has a focus its pro-oxidant effects [3], [4], which has perhaps coloured perceptions of its function