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However, because the downstream signaling components remain intact in this condition, patients can often be successfully treated with exogenous cytokine therapy to bypass the defect and directly stimulate macrophage microbicidal activity

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There are essentially two types of the lysosomal membrane disintegrity: ‘pores’ indicate the perforations being so small which could be made by a microneedle, and cannot be detected by electron microscopy, whereas ‘holes’ indicate the discontinuous lysosomal limiting membrane being detected on the electron microphotographs