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Interestingly, treatment with BH4 supplementation showed reduced NOS-dependent generation of superoxide [62] and restored endothelial function [63, 64], indicating that BH4 may be an ideal target for oxidative stress-induced “uncoupling” and endothelial dysfunction

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[DOI] [PubMed] [Google Scholar] 142.Schroeder E.K., Kelsey N.A., Doyle J., Breed E., Bouchard R.J., Loucks F.A., Harbison R.A., Linseman D.A