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Interestingly, copper was found to directly bind to lipoylated TCA cycle proteins, leading to disulfide-bond-dependent aggregation of these proteins and degradation of iron-sulfur (Fe-S) cluster proteins

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Methods: Male and female C57BL/6 mice were fed a high-fat diet (HFD) and administered either vehicle control or chlordane(20 mg/kg)+PCB126(20µg/kg) over a 12-week period