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242 Cysteine-rich intestinal protein 1 (CRIP1) activates NF-κB signaling and upregulates CXCL1/5 expression to recruit MDSCs, leading to an immunosuppressive environment in pancreatic ductal adenocarcinoma

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Reduced tissue concentration of SAM may be linked to depression through perturbing monoamine (serotonin, dopamine and noradrenaline) synthesis and methylation (Reference Smith and Refsum68)