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Three-dimensional structures are known for a number of the relevant enzymes, including mycobacterial EgtB (101) for example, PDB 4XBE, EgtC (102) for example, PDB 4ZFJ, EgtD (103–105) for example, PDB 4PIM, and Neurospora crassa early G1 transcript 2 (egt2) which is like egtE (106) for example, PDB 5UTS