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Similarly, given the recent work characterizing the uniqueness and heterogeneity of EECs 81,84,85,86,87 , it may also be possible to target specific populations of EECs or even convert certain EECs into cells that secrete specific peptides 302,303,304

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Although PUFA stimulation (but not cytokines, bile acids or lipopolysaccharide) impaired epithelial GPX4 activity likely because of proteasomal degradation of GPX4 (Supplementary Fig