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DSIP was discovered in 1977 as a nonapeptide found in the cerebral venous blood of rabbits during electrically induced sleep, while oveporexton is a 21st-century small molecule agonist targeting the orexin receptor 2 with precision pharmacology

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Alliin has been identified as a multitarget autophagy modulator through the integration of target prediction, PPI-network analysis, GO/KEGG enrichment, docking, and experimental results