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Briefly, Nrf2 is a transcription factor that is bound to the protein Kelch-like ECH-associated protein 1 (Keap1) in the cytosol

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HIF-1α promotes the expression of glucose transporters (GLUT1 and GLUT3) and at least eight of the ten glycolytic enzymes (HK, PFK, ALD-A, GAPDH, PGK, ENO, PKM and LDH-A) [431–433] (figure 3 B.3 ), allowing an increased flux through the pathway and maintenance of cellular ATP production under hypoxic conditions and promoting in turn an increase in cell proliferation and angiogenesis [433]