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· New England Journal of Medicine · 2021 04 Tirzepatide Once Weekly for the Treatment of Obesity Jastreboff AM, Aronne LJ, Ahmad NN, et al

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After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator γ-H2AX were markedly elevated (Figure 3B)