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The multitude of targets can be specific given the activation of the VEGFR2-Akt-eNOS signaling pathway without the need for other known ligands or shear stress and evidenced controlling vasomotor tone by the activation of the Src-Caveolin-1-eNOS pathway [121,122]

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Several dietary and genetic factors, including folate, vitamin B 6 , and vitamin B 12 deficiency, and known genetic variants of the MTHFR and CBS genes, influence the efficiency of H 2 S production, and could be important contributors to hypertension in these individuals, which may also explain individual responsiveness to garlic supplementation seen in clinical trials

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