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2.3 The relationship between ferroptosis and other programmed cell death responses Ferroptosis is intricately linked to biological processes, including autophagy, endoplasmic reticulum stress, and inflammation, among others, and may be involved in the reciprocal regulation of recalcitrant diseases

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Similar phenomena exist in clinical studies: some patients treated with immunotherapy are evaluated as having “stable disease” by RECIST but exhibit immune activation characteristics in the TME