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In addition to systemically derived IGF-1, this anabolic and neuroactive peptide is produced locally in the brain and is involved in a wide range of homeostatic and developmental processes including gliogenesis, oligodendrocyte maturation, myelination, axon growth, and regulation of cell survival (Bartlett et al., 1992

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What Clinical Evidence Says About Combining These Compounds No randomized controlled trials have directly studied tirzepatide plus NAD+ supplementation in humans