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Glossary Abbreviations AA/aa amino acid npAA non-proteinogenic amino acid pAA proteinogenic amino acid bRo5 beyond the rule of 5 aaRS aminoacyl-tRNA synthetase APBA acetylphenylboronic acid Bcl-2 B-cell lymphoma 2 Bcl-9 B-cell lymphoma 9 ClAc chloroacetyl CKP cysteine-knot peptide Dha dehydroalanine Dhb dehydrobutyrine mCNP meta -cyanopyridine CPP cell-penetrating peptide DARPin designed ankyrin repeat protein DEL DNA-encoded chemical library FACS fluorescence-assisted cell sorting FBDD fragment-based drug discovery Fc fragment crystallizable FDA American Food and Drug Administration FIT flexible in vitro translation GABARAP γ-aminobutyric acid A receptor GTP/GDP guanosine triphosphate/guanosine diphosphate HBS hydrogen-bond surrogate HGF hepatocyte growth factor HIF1 hypoxia-inducible factor HIV human immunodeficiency virus HTS high-throughput screening IDP intrinsically disordered protein LRP6 low-density lipoprotein receptor-related protein 6 MAGE-A4 melanoma associated antigen 4 MIPD mirror-image phage display NEL nucleotide-encoded library NELS nucleotide-encoded library screening NGS next-generation sequencing pIII M13 phage protein III OBOC one-bead-one-compound PCR polymerase chain reaction PAMPA parallel artificial membrane permeability assay PK/PD pharmacokinetics/pharmacodynamics PEG polyethlyene glycol PPI protein–protein interaction ProP-PD proteomic-peptide phage display PROTAC proteolysis targeted chimera PylRS pyrrolysil-tRNA synthetase RaPID random nonstandard peptide integrated discovery RCM/ROM ring-closing metathesis/ring-opening metathesis RiPP ribosomally synthesized and post-translationally modified peptide SICLOPPS split intein-mediated circular ligation of peptides and proteins SLiMS short linear motifs SPPS solid-phase peptide synthesis TBMB tribromomethylbenzene Biographies Kilian Colas obtained his M.Sc