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Oral bacteria can colonize the gut when swallowed in large quantities (during oral inflammation or periodontitis), with some strains surviving stomach acid through biofilm protection or inherent tolerance, while preexisting gut inflammation creates a favorable environment for their establishment by reducing microbial diversity and stability (Newman and Kamada, 2022)

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Figure 1 The interior surface of LVs (capillaries, pre-collecting and collecting vessels) is lined by a single layer of LECs that constitutes the lymphatic endothelium