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The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutide’s 13.7%.¹ ² Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss.⁷ ¹⁷ That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

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In addition to the old age and a high ASA score of patients, a low preoperative hemoglobin level was a risk factor (odds ratio [OR], 0.541