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SKN-1, for instance, has been shown to intersect with HIF-1 signaling to regulate oxidative stress responses and metabolic adaptation to hypoxia [136, 137]

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Furthermore, the length of time associated with stimulation and the L-Glu concentration are important factors that will influence cell survival and death [132], and these vary between studies and, for some, may represent the application of supraphysiological L-Glu concentrations [133]