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Neoplastic antigens can trigger a T-helper-mediated hypersensitivity reaction, activating monocytes and forming epithelioid histiocytes [28]

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For that, the γ-glutamate-cysteine ligase (GshA) condenses the carboxyl group at the γ-position of glutamate with the amino group of cysteine, creating the dipeptide γ-glutamyl-cysteine