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While individuals with some monogenic causes, such as Angelman Syndrome (AS), Fragile X Syndrome (FXS), and Rett Syndrome (RTT) [8,9,10], have features of ASD, the etiology of ASD as a whole is extremely heterogeneous [11, 12]

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In addition, MMP13, which plays a crucial role in the degradation of extracellular matrix 36 , was significantly decreased in the knee joints following L-Gln treatment