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Introduction Head and neck squamous cell carcinomas (HNSCC) are loco-regionally aggressive tumors that result in debilitating functional and esthetic sequelae in approximately half a million individuals worldwide [ One strategy to accomplish this goal involves assessing the anticancer activity of existing Food and Drug Administration (FDA) approved drugs used for non-oncologic indications, a concept termed as drug repurposing or repositioning [ Neural Regulation of Cancer The role of nerves in cancer patients, particularly in the context of cancer pain, has been long recognized [ Neural Signaling and Adrenergic Stress in HNSCC Head and neck cancers were among the first set of cancers that showed propensity to grow along nerves [ Krt5 Cre Trp53 flox / flox mice, the authors demonstrated increased nerve density in p53 deficient tumors compared to wild type p53 controls implicating the loss of p53 in epithelial cells with neuritogenesis during oral carcinogenesis
