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However, under oxidative stress, cysteine residues on KEAP1 are modified, altering its conformation and disrupting its association with NRF2 and subsequent NRF2 stabilization (Taguchi and Yamamoto, 2017)

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For example, sequentially combining mild hypothermia with recombinant high-density lipoprotein effectively improved multiple pathological indicators in TBI mouse models compared to that of hypothermia treatment alone