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Reversible and asymptomatic elevations in transaminases were the primary adverse effects when CB-839 monotherapy was used to treat hematologic malignancies and solid tumors in clinical trials (226–228)

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Supplementation using NO precursors such as L-arginine and beetroot extracts, as well as LC, resulted in a significant increase in circulating 25(OH)VD levels and a decrease in oxidative stress and inflammation [147]

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