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During the 12 h-observation period, vehicle-treated rats consumed an amount of food corresponding to 54.1±2.1 kcal, whereas acute treatment with the highest dose of tesofensine (3.0 mg/kg) resulted in a total food intake amounting to 12.6±3.9 kcal, being equivalent to a 77% reduction of energy intake

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This structural modification is what makes Semax viable as a pharmaceutical