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Abbreviations: ATP Adenosine triphosphate BRJ Beetroot juice BH 2 Dihydrobiopterin BH 4 Tetrahydrobiopterin (NOS cofactor) cGMP Cyclic guanosine monophosphate DeoxyHb Deoxygenated hemoglobin DeoxyMb Deoxygenated myoglobin DNRA Dissimilatory nitrate reduction to ammonium eNOS Endothelial nitric oxide synthase FMD Flow-mediated dilation Hb Hemoglobin HFrEF Heart failure with reduced ejection fraction HIIT High-intensity interval training HNO Nitroxyl HNO 2 Nitrous acid iNOS Inducible nitric oxide synthase Mb Myoglobin mtNOS Mitochondrial nitric oxide synthase N 2 O 3 Dinitrogen trioxide NADPH Nicotinamide adenine dinucleotide phosphate (reduced form) NH 4 + ammonium NiR Nitrite reductase NO Nitric oxide NO 2 − Nitrite NO 3 − Nitrate NO + Nitrosonium ion NOS Nitric oxide synthase NR Nitrate reductase (bacterial) NRB Nitrate-reducing bacteria ONOO − Peroxynitrite pH Hydrogen ion concentration RBC Red blood cells ROS Reactive oxygen species RSNO S-nitrosothiols sGC Soluble guanylyl cyclase SIT Sprint interval training O 2 Oxygen uptake O 2 max Maximal oxygen uptake O 2 peak Peak oxygen uptake XO Xanthine oxidase XOR Xanthine oxidoreductase 1

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Phentermine is a daily stimulant pill and Compounded Semaglutide is a weekly GLP-1 injection