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In summary, selenium deficiency can impact all aspects of the immune system, while selenium supplementation can improve cellular immunity, humoral immunity, and nonspecific immune functions

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Additionally, celastrol, a compound with antioxidant and anti-inflammatory effects, reduces CyPA and Bsg expression, reducing ROS production and improving pressure-overload-induced cardiac dysfunction and postcapillary PH, showing the role of oxidative stress in the development of PH-LHD