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It is believed that APAP overdose can cause mitochondria damage and APAP-ADs accumulation in hepatocytes, resulting in hepatic necrosis and liver injury [75]

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Sci Signal 4:rs12 Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B et al (2020) Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A