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FIGURE 7 Discussion Acetaminophen is one of the most widely used analgesic and antipyretic over-the-counter drugs in the world ( It has been documented that PA administration provided protection through metal chelation and its antioxidant properties ( The present data based on APAP-induced hepatotoxicity in mice identified that PA treatment for 7 days at a dose of 200 mg/kg/day has critical actions in modulating APAP-induced liver toxicity in mice

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The ERK pathway activates kinases such as p90RSK and MSK1, which phosphorylate CREB at Ser133