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Fe 2+ overload, ROS accumulation, GSH depletion, LPO, and mitochondrion shrinkage were observed in HSV-1-infected cultured human astrocytes, microglia and murine brains, which are hallmarks of ferroptosis (Xu et al., 2023).The ways of ferroptosis induced by HSV are related to Nrf2, GSH-GPX4 and dihydroorotate dehydrogenase-dihydroubiquione (DHODH-CoQH2) (Mao et al., 2021

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In fact, most of your cells have an enzyme called gamma glutamyltransferase on them