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Consequently, stabilized Nrf2 undergoes nuclear translocation and forms a heterodimer with small Maf (sMAF) proteins

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At the cellular level, transferrin (TF) mediates the cellular uptake of Fe 3+ via endocytosis of iron-loaded TF-bound transferrin receptor 1 (TFR1), followed by release from the endosome, 93,94 in which Fe 3+ is then converted to Fe 2+ via the metalloreductase STEAP3

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