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Majerníková N, Marmolejo-Garza A, Salinas CS, et al

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Chronic administration of L-theanine (250 mg/d for 8 wk) has also been found to be safe in patients with major depressive disorder, it even exhibited multiple beneficial effects against major depressive disorder symptoms including cognitive impairments, sleep disturbance, anxiety, and so on (Hidese et al., 2017)