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Huberman considers pairing vitamin D3 with vitamin K2 a key consideration for preserving cardiovascular function over a long-term time course due to vitamin K2’s protective effects on the vasculature

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50,51 Both the endogenous LPP and its biochemically synthesized counterpart have been demonstrated to be capable of stimulating the synthesis of aggrecan and collagen II in cartilage stem/progenitor cells 52 and intervertebral disk cells