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But if untreated, it may lead to symptoms such as: Weakness, tiredness, or lightheadedness Heart palpitations and shortness of breath Pale skin A smooth tongue Constipation, diarrhea, loss of appetite, or gas Nerve problems such as numbness or tingling, muscle weakness, and problems walking Vision loss Mental health problems such as depression, memory loss, or behavioral changes Deficiency of Vitamin B12 affects more women than men, and can be due to: Lack of intrinsic factor, a substance produced in the stomach that is necessary for the absorption of Vitamin B12 from food