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NG497 is the first human-specific ATGL small-molecule inhibitor that targets the patatin-like domain of human ATGL enzyme activity, eliminating the hormone-stimulated FA release in adipocytes (130)

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Debes 4,5,6 , (1)University of Minnesota, Minneapolis, Minnesota, Minneapolis, MN, (2)University of California, San Francisco, (3)Arusha Lutheran Medical Center, (4)Erasmus University Medical Center, Netherlands, (5)Hennepin Healthcare, (6)University of Minnesota Background: Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) are associated with higher morbidity and mortality in Africa, particularly in rural areas, in part due to lack of identification of patients with HBV and lack of feasible surveillance programs for HCC