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doi:10.1016/j.archger.2010.10.004 [Trial terminated early for a congestive-heart-failure safety signal.] 37

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[1] Spike-timing-dependent plasticity (STDP), where a presynaptic neuron firing just milliseconds before a postsynaptic neuron leads to synaptic strengthening (timing-based long-term potentiation LTP), while firing after the postsynaptic neuron causes weakening (timing-based long-term depression LTD)