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Method: A randomized controlled pilot study is conducted including 30 patients who have undergone LT: (1) intervention group (n=15) receiving, in addition to the standard nutritional care, supplements rich in protein, HMB and energy for 12 weeks and (2) control group (n=15) receiving standard nutritional care

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This intranasal formulation is administered shortly before target sleep time, and the intranasal route provides fast CNS delivery that maximizes the overlap between peak DSIP levels and sleep onset

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