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As a unique form of programmed cell death, ferroptosis relies on iron ions and reactive oxygen species (ROS) to induce lipid peroxidation, leading to cell death, completely distinguishing it from apoptosis, autophagy and necrosis at the morphological, molecular and genetic levels [7]

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However, a subsequent 24-week Phase IIb obesity trial involving 536 adults failed to demonstrate sufficient weight-loss efficacy, and development of AOD-9604 as an obesity treatment was discontinued