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During further erythroid differentiation and maturation, a switch in isoenzymes occurs whereby progressively increased PK-R expression gradually replaces PK-M2 (Gray et al., 2014)

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Also, air pollution exposure can cause thyroid diseases, and studies have considered the effects of carbon monoxide (CO), nitrogen dioxide (NO 2 ), sulfur dioxide (SO 2 ), ozone (O 3 ), and particulate matter 10 mg/L (38)