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Sulfonylureas bind to sulfonylurea receptors (SURs) and act by blocking ATP-sensitive K + -channels in the pancreatic β-cell plasma membrane, leading to the inhibition of K + efflux, membrane depolarization, the opening of voltage-gated Ca 2+ channels, an influx of Ca 2+ , and the triggering of insulin secretion by exocytosis [101,102,103]