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16α-OHE 2 is a potent ER agonist, capable of levels of cellular proliferation stimulation that near those obtained with E 2

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1 H NMR (400 MHz, CDCl 3 ): δ 10.01 (br s, 1H, NH), 7.74 (d, J = 8.0 Hz, 1H, indole-H4), 7.56 (ddd, J = 8.0, 1.2, 0.9 Hz, 1H, indole-H7), 7.43 (ddd, J = 8.2, 7.6, 1.4 Hz, 1H, indole-H6), 7.34 (ddd, J = 8.4, 7.2, 1.0 Hz, 1H, indole-H5), 3.96 (s, 2H, CH 2 ), 2.65–2.61 (m, 2H, CH 2 ), 2.17 (s, 3H, CH 3 ), 1.55 (br s, 1H, NH), 1.26 (s, 3H, CH 3 )