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In patients who may be susceptible to the intracranial effects of CO2 retention (e.g., those with evidence of increased intracranial pressure or brain tumors), hydrocodone bitartrate and acetaminophen tablets may reduce respiratory drive, and the resultant CO2 retention can further increase intracranial pressure

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To test whether endogenous mGluR5 affects myelination, we established mutants that disrupt mGluR5 using CRISPR-Cas9 (Methods) and identified mutations that resulted in premature stop codons in the open reading frames of both grm5a and grm5b (Fig