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This decline in the GHK-level coincides with a dramatic decrease in the regenerative capacity of all mammals.[1] It is possible that the sharp reduction in GHK-Cu during normal aging reduces the expression of protective anti-cancer genes and increases risk of cancer

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Moreover, inclusion of young premenopausal women eliminates confounding factors, such as chronic diseases, which may underestimate the magnitude of the effect of estrogens on antioxidant and longevity-related genes