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Vitamin B12 supplementation is carried out until the deficiency is remedied, and if the factor causing the deficiency is not removed, continuous cobalamin supplementation is necessary

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The 2025 PMC review “BPC-157: Regeneration or Risk?” (Seiwerth et al.) represents the most recent major systematic review, covering the mechanistic literature and explicitly acknowledging the angiogenesis-cancer gap as the primary unresolved safety question