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MTP-131) is a synthetic cell-permeable tetrapeptide developed by Hazel Szeto and Peter Schiller, featuring an alternating aromatic–cationic residue pattern — D-Arg-Dmt-Lys-Phe-NH₂ — where Dmt denotes 2′,6′-dimethyltyrosine

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NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink