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doi:10.2174/1389557519666190119111125 Kawahara M, Tanaka KI, Kato-Negishi M

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Abbreviations Used ACC acetyl-CoA carboxylase AgRP agouti-related protein AMPK AMP-activated protein kinase BAT brown adipose tissue BMI body mass index CACT acylcarnitine translocase CPT1 carnitine palmitoyltransferase 1 CPT1A liver CPT1 CT computed tomography DAG diacylglycerol ETC electron transport chain FA fatty acid FAO fatty acid oxidation FAS fatty acid synthase FFA free fatty acid FGF21 fibroblast growth factor 21 HFD high-fat diet IMC intramyocellular LCFA-CoA long-chain fatty acid-CoA MCD malonyl-CoA decarboxylase NAFLD nonalcoholic fatty liver disease NASH nonalcoholic steatohepatitis NPY neuropeptide Y PET positron-emission tomography ROS reactive oxygen species SkM skeletal muscle TCA tricarboxylic acid TG triglyceride UCPs uncoupling proteins UPR uncoupled protein response WAT white adipose tissue Acknowledgments We thank Professor Fausto G