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Importantly, JAK inhibitors (e.g., tofacitinib) have shown significant efficacy in the treatment of UC, further validating the feasibility of the JAK/STAT pathway as a therapeutic target ( 3 Role of JAK/STAT pathway in the pathogenesis of UC 3.1 Influence on inflammatory response The JAK2/STAT3 axis is a major pathway for transcription factors associated with mediating proinflammatory cytokine in intestinal mucosal inflammation