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The case of NAC encapsulates the core challenges of MIRI therapy: while its mechanism of enhancing endogenous defenses is conceptually superior to direct scavenging (as argued in Section 2.3), its clinical potential is ultimately nullified by the formidable practical hurdles of delivery and timing required to counteract the rapid and localized oxidative burst (Section 2.1)

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Key Elements to Manage a D&C Contract During the delivery phase, it is essential that the owner’s team: Can proactively manage and mitigate variations