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In the CENTAUR trial which was a placebo-controlled, double-blind, multicenter and randomized study, the effectiveness and safety of sodium phenylbutyrate-taurursodiol (PB-TURSO) were confirmed in the patients with ALS (21)

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The Metabolism of Melanin Synthesis Melanin biosynthesis is initiated from the conditionally nonessential amino acid tyrosine, which is obtained either through dietary intake or via endogenous synthesis from the essential amino acid phenylalanine