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Actual out-of-pocket cost depends heavily on: Insurance coverage — many plans cover these drugs for diabetes more readily than for weight management Indication — coverage and pricing differ between the diabetes and obesity brands Manufacturer savings programs and regional pricing Supply — both products have experienced periodic shortages driven by surging demand Tirzepatide's commercial success illustrates the scale of this market: its diabetes brand generated roughly $10 billion in a single quarter in 2025

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This directly challenges the prevailing dogma derived from tissue-specific animal studies and suggests that systemic blood levels are tightly homeostatically regulated, potentially serving as a reservoir that is only depleted in severe pathology