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Glutathione gets hyped as the “master antioxidant” that detoxes your body and slows aging — but does it really live up to the hype? Your body already makes glutathione naturally from amino

if mitophagy is excessive or coexists with iron homeostasis imbalance, it may promote iron release and energy failure, further increasing susceptibility to ferroptosis (190)

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This is the case for deglutathionylation of GAPDH by GRXC1 [224], TPI by GRXC1 and GRXC2 [253], and RTL1 by GRXC1 [284]